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1

Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5 H -dibenz[ b , f ]azepine-5-carboxamide Derivatives

Benes, Jan, Parada, António, Figueiredo, Anabela A., Alves, Paula C., Freitas, Ana P., Learmonth, David A., Cunha, Rodrigo A., Garrett, José, Soares-da-Silva, Patrício

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 84 KB

english, 1999

2

Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

Ferreira, Joaquim J, Lees, Andrew, Rocha, José-Francisco, Poewe, Werner, Rascol, Olivier, Soares-da-Silva, Patrício

Journal:

The Lancet Neurology

Année:

2015

Langue:

english

Fichier:

PDF, 416 KB

english, 2015

3

Catechol-O-methyltransferase and Its Inhibitors in Parkinson's Disease

Maria João Bonifácio, P. Nuno Palma, Luís Almeida, Patrício Soares-da-Silva

Journal:

CNS Drug Reviews

Année:

2007

Langue:

english

Fichier:

PDF, 8.03 MB

english, 2007

4

Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much “fair” is “fair”

Trinka, Eugen, Rocha, José Francisco, Soares-da-Silva, Patrício

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 234 KB

english, 2018

5

Eslicarbazepine Acetate (BIA 2-093)

Luis Almeida, Patrício Soares-da-Silva

Journal:

Neurotherapeutics

Année:

2007

Langue:

english

Fichier:

PDF, 584 KB

english, 2007

6

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Ana Fortuna, Joana Sousa, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva

Journal:

Analytical and Bioanalytical Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 210 KB

english, 2010

7

Disposition of eslicarbazepine acetate in the mouse after oral administration

Gilberto Alves, Isabel Figueiredo, Margarida Castel-Branco, Nulita Lourenço, Amílcar Falcão, Margarida Caramona, Patrício Soares-da-Silva

Journal:

Fundamental & Clinical Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 167 KB

english, 2008

8

Eslicarbazepine Acetate: A Double-blind, Add-on, Placebo-controlled Exploratory Trial in Adult Patients with Partial-onset Seizures

Christian Elger, Meir Bialer, Joyce A. Cramer, Joana Maia, Luis Almeida, Patrício Soares-da-Silva

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 200 KB

english, 2007

9

Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024

António F. Ambrósio, Patrício Soares-da-Silva, Caetana M. Carvalho, Arsélio P. Carvalho

Journal:

Neurochemical Research

Année:

2002

Langue:

english

Fichier:

PDF, 57 KB

english, 2002

10

Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase

Kiss, László E., Ferreira, Humberto S., Torrão, Leonel, Bonifácio, Maria João, Palma, P. Nuno, Soares-da-Silva, Patrício, Learmonth, David A.

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2010

11

Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone

Maria João Bonifácio, Ana I. Loureiro, Leonel Torrão, Carlos Fernandes-Lopes, Lyndon Wright, Maria João Pinho, Patrício Soares-da-Silva

Journal:

Biochemical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 420 KB

english, 2009

12

Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures

E. Perucca, C. Elger, P. Halász, A. Falcão, L. Almeida, P. Soares-da-Silva

Journal:

Epilepsy Research

Année:

2011

Langue:

english

Fichier:

PDF, 285 KB

english, 2011

13

Bioavailability and Bioequivalence of Two Enteric-Coated Formulations of Omeprazole in Fasting and Fed Conditions

Manuel Vaz-da-Silva, Ana I. Loureiro, Dr Teresa Nunes, Joana Maia, Susana Tavares, Amilcar Falcão, Pedro Silveira, Luis Almeida, Patricio Soares-da-Silva

Journal:

Clinical Drug Investigation

Année:

2005

Langue:

english

Fichier:

PDF, 125 KB

english, 2005

14

Pharmacokinetics, Drug Interactions and Exposure-Response Relationship of Eslicarbazepine Acetate in Adult Patients with Partial-Onset Seizures

FalcÃ£o, Amilcar, Fuseau, Eliane, Nunes, Teresa, Almeida, Luis, Soares-da-Silva, Patricio

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 403 KB

english, 2012

15

Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

Bonifácio, M.J., Sutcliffe, J.S., Torrão, L., Wright, L.C., Soares-da-Silva, P.

Journal:

Neuropharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 768 KB

english, 2014

16

Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers

Elger, Christian, Bialer, Meir, Falcão, Amílcar, Vaz-da-Silva, Manuel, Nunes, Teresa, Almeida, Luís, Soares-da-Silva, Patrício

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 363 KB

english, 2013

17

Blood pressure decrease in spontaneously hypertensive rats folowing renal denervation or dopamine β-hydroxylase inhibition with etamicastat

Pires, Nuno Miguel, Igreja, Bruno, Moura, Eduardo, Wright, Lyndon Christopher, Serrão, Maria Paula, Soares-da-Silva, Patrício

Journal:

Hypertension Research

Année:

2015

Langue:

english

Fichier:

PDF, 1024 KB

english, 2015

18

Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects

Damasceno, Albertino, Santos, Alejandro, Serrão, Paula, Caupers, Paula, Soares-da-Silva, Patrício, Polónia, Jorge

Journal:

Journal of Hypertension

Année:

1999

Langue:

english

Fichier:

PDF, 215 KB

english, 1999

19

Pooled efficacy of opicapone as adjunctive therapy to levodopa in patients with Parkinson’s disease and motor fluctuations

Ferreira, Joaquim, Lees, Andrew, Lopes, Nelson, Santos, Ana, Rocha, Jose-Francisco, Soares-da-Silva, Patricio

Journal:

Parkinsonism & Related Disorders

Année:

2016

Langue:

english

Fichier:

PDF, 229 KB

english, 2016

20

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations

Lees, Andrew J., Ferreira, Joaquim, Rascol, Olivier, Poewe, Werner, Rocha, José-Francisco, McCrory, Michelle, Soares-da-Silva, Patricio

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 296 KB

english, 2017

21

Opicapone improves the effects of l-dopa on the mptp-induced parkinson’s-like syndrome in cynomolgus monkeys

Bonifácio, M.J., Sousa, F., Soares-da-Silva, P.

Journal:

Journal of the Neurological Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 367 KB

english, 2017

22

COLOUR PROFILE ANALYSIS OF PORT WINES BY DIFFERENT INSTRUMENTAL AND VISUAL METHODS

Soares-da-Silva, Francisco Almeida Garrett, Campos, Francisco Manuel, Ferreira, Manuel Lima, Ribeiro, Natália, Amaral, Bento, Simões, Tomás, Silva, Cristina Luísa Miranda

Journal:

Journal of the Science of Food and Agriculture

Année:

2019

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2019

23

Efficacy of opicapone in Parkinson’s disease patients according to baseline pramipexole use: A post-hoc analysis from combined BIPARK-I and II

Lees, A., Ferreira, J., Rascol, O., Poewe, W., Stocchi, F., Santos, A., Magalhaes, D., Rocha, F., Soares-da-Silva, P.

Journal:

Journal of the Neurological Sciences

Année:

2019

Fichier:

PDF, 219 KB

2019

24

Regulatory safety pharmacology evaluation of BIA 10-2474

Hayes, A. Wallace, Pressman, Peter, Moser, Paul, Soares-da-Silva, PatrÃcio

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2020

Langue:

english

Fichier:

PDF, 2.72 MB

english, 2020

25

Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial

Kirkham, Fenella, Auvin, StÃ©phane, Moreira, Joana, Gama, Helena, FalcÃ£o, AmÃlcar C., Rocha, JosÃ©-Francisco., Soares-da-Silva, PatrÃcio

Journal:

Epilepsy & Behavior

Année:

2020

Fichier:

PDF, 1.93 MB

2020

26

Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker

Amílcar Falcão, Joana Maia, Luis Almeida, Dago Mazur, Manfred Gellert, Patrício Soares-da-Silva

Journal:

Biopharmaceutics & Drug Disposition

Année:

2007

Langue:

english

Fichier:

PDF, 129 KB

english, 2007

27

Binding of licarbazepine enantiomers to mouse and human plasma proteins

Ana Fortuna, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva

Journal:

Biopharmaceutics & Drug Disposition

Année:

2010

Langue:

english

Fichier:

PDF, 94 KB

english, 2010

28

ChemInform Abstract: Synthesis, Anticonvulsant Properties and Pharmacokinetic Profile of Novel 10,11-Dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide Derivatives.

David A. Learmonth, Jan Benes, Antonio Parada, Dominik Hainzl, Alexander Beliaev, Maria Joao Bonifacio, Pedro M. Matias, Maria A. Carrondo, Jose Garrett, Patricio Soares-da-Silva

Journal:

Année:

2001

Fichier:

PDF, 32 KB

2001

29

Stereoselective disposition of S- and R-licarbazepine in mice

Gilberto Alves, Isabel Figueiredo, Amílcar Falcão, Margarida Castel-Branco, Margarida Caramona, Patrício Soares-DA-Silva

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 168 KB

english, 2008

30

5-Hydroxytryptamine and alcoholism

Luis Ferreira, P. Soares-Da-Silva

Journal:

Human Psychopharmacology: Clinical and Experimental

Année:

1991

Langue:

english

Fichier:

PDF, 427 KB

english, 1991

31

Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity

C. Calhau, F. Martel, S. Pinheiro-Silva, H. Pinheiro, P. Soares-da-Silva, C. Hipólito-Reis, I. Azevedo

Journal:

Journal of Cellular Biochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 215 KB

english, 2002

32

H2O2 stimulates Cl−/HCO exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells

Sónia Simão, Pedro Gomes, Maria João Pinho, Patrício Soares-da-Silva

Journal:

Journal of Cellular Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 268 KB

english, 2011

33

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: Multisubstate relative free energy calculations

P. Nuno Palma, Maria João Bonifácio, Ana Isabel Loureiro, Patrício Soares-da-Silva

Journal:

Journal of Computational Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 4.21 MB

english, 2012

34

Protein cytoskeleton and overexpression of Na+,K+-ATPase in opossum kidney cells

Elisabete Silva, Patrício Soares-da-Silva

Journal:

Journal of Cellular Physiology

Année:

2009

Langue:

english

Fichier:

PDF, 278 KB

english, 2009

35

Long-term regulation of Na+,K+-ATPase in opossum kidney cells by ouabain

E. Silva, P. Soares-da-Silva

Journal:

Journal of Cellular Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 619 KB

english, 2011

36

Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives

Ana Fortuna, Gilberto Alves, Patrício Soares-da-silva, Amílcar Falcão

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 271 KB

english, 2012

37

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites

Ana Fortuna, Joana Bicker, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva

Journal:

Journal of Separation Science

Année:

2011

Langue:

english

Fichier:

PDF, 331 KB

english, 2011

38

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

Luis Almeida, Manuel Vaz-da-Silva, Amílcar Falcão, Eva Soares, Raquel Costa, Ana I. Loureiro, Carlos Fernandes-Lopes, José-Francisco Rocha, Teresa Nunes, Lyndon Wright, Patrício Soares-da-Silva

Journal:

Molecular Nutrition & Food Research

Année:

2009

Langue:

english

Fichier:

PDF, 277 KB

english, 2009

39

A COMPARATIVE STUDY ON THE SYNTHESIS OF THE NATRIURETIC HORMONE DOPAMINE IN OK AND LLC-PK1CELLS

P. SOARES-DA-SILVA, M.P. SERRÃO, M.A. VIEIRA-COELHO

Journal:

Cell Biology International

Année:

1996

Langue:

english

Fichier:

PDF, 231 KB

english, 1996

40

OPOSSUM KIDNEY CELLS TAKE UP L-DOPA THROUGH AN ORGANIC CATION POTENTIAL-DEPENDENT AND PROTON-INDEPENDENT TRANSPORTER

P GOMES, M.P SERRÃO, M.A VIEIRA-COELHO, P SOARES-DA-SILVA

Journal:

Cell Biology International

Année:

1997

Langue:

english

Fichier:

PDF, 151 KB

english, 1997

41

INHIBITION OF CALCIUM-INDEPENDENT LUMINAL UPTAKE OF L-DOPA BY CALMODULIN ANTAGONISTS IN IMMORTALIZED RAT CAPILLARY CEREBRAL ENDOTHELIAL CELLS

B. Sampaio-Maia, P. Soares-Da-Silva

Journal:

Cell Biology International

Année:

2001

Langue:

english

Fichier:

PDF, 133 KB

english, 2001

42

A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography

L.A. Passarinha, M.J. Bonifácio, P. Soares-da-Silva, J.A. Queiroz

Journal:

Journal of Chromatography A

Année:

2008

Langue:

english

Fichier:

PDF, 638 KB

english, 2008

43

Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy

E. Ben-Menachem, A.A. Gabbai, A. Hufnagel, J. Maia, L. Almeida, P. Soares-da-Silva

Journal:

Epilepsy Research

Année:

2010

Langue:

english

Fichier:

PDF, 366 KB

english, 2010

44

Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives

David A Learmonth, Jan Benes, António Parada, Dominik Hainzl, Alexander Beliaev, Maria João Bonifácio, Pedro M Matias, Maria A Carrondo, José Garrett, Patrı́cio Soares-da-Silva

Journal:

European Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 182 KB

english, 2001

45

Catechol-O-methyltransferase Inhibition in Erythrocytes and Liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone)

Patrício Soares-da-Silva, Maria A. Vieira-Coelho, António Parada

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

2003

Langue:

english

Fichier:

PDF, 135 KB

english, 2003

46

Effect of salt intake on jejunal dopamine, Na+,K+-ATPase activity and electrolyte transport

Lucas-Teixeira, Serrão, Soares-Da-Silva

Journal:

Acta Physiologica

Année:

2000

Langue:

english

Fichier:

PDF, 302 KB

english, 2000

47

Response of jejunal Na+, K+-ATPase to 5-hydroxytryptamine in young and adult rats: Effect of fasting and refeeding

Lucas-Teixeira, SerrÃo, Soares-Da-Silva

Journal:

Acta Physiologica

Année:

2000

Langue:

english

Fichier:

PDF, 267 KB

english, 2000

48

Regulation of apical transporter of L-DOPA in human intestinal Caco-2 cells

S. FRAGA, B. SAMPAIO-MAIA, M. P. SERRÃO, P. SOARES-DA-SILVA

Journal:

Acta Physiologica

Année:

2002

Langue:

english

Fichier:

PDF, 213 KB

english, 2002

49

Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells

P. GOMES, P. SOARES-DA-SILVA

Journal:

Acta Physiologica

Année:

2002

Langue:

english

Fichier:

PDF, 317 KB

english, 2002

50

P-glycoprotein phosphorylation/dephosphorylation and cellular accumulation of L-DOPA in LLC-GA5 Col300 cells

B. Sampaio-Maia, R. Gomes, P. Soares-da-Silva

Journal:

Autonomic and Autacoid Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 141 KB

english, 1999